Improving scar development after myocardial infarction

06.10.2023 Doktorarbeit experimentell


Our group is interested in the identification of potential new targets as well as mechanisms involved in the progression of organ fibrosis, dysfunction and failure with special regard (but not limited) to the heart (

The prospective candidate will work in an ongoing project focused on the progress of scar development and tissue remodelling after an acute myocardial infarction. Different cell types, like Fibroblasts and epicardial cells, are of importance during scar remodelling after ischemic injury and cardiomyocyte death. Results so far show an improvement of cardiac functions and scar development in transgenic mice, with specific transcriptional factor deletion in these cell types, after acute myocardial infarction, making it a possible therapeutical target.

For this project, Tissue samples and isolated cells of the transgenic mice will be analysed regarding the effects of the transcriptional factor deletion. Well-established molecular and cell biology techniques will be used for histologic, protein and RNA analysis, including western blotting, RNA-Isolation, qPCR, immunostaining, microscopy and more. In addition, analysis of in-vivo experiments (Echocardiography etc.) will be part of the project. If desired, we support training courses for in vivo experiments to enable you to perform these vivo experiments yourself. Lab experience is welcome but you will be taught all techniques in our lab.

We also support the application for MD Fellowships (1034€/month) by intra- or extramural stipends (Promotionsstipendium der medizinischen Fakultät Mannheim, CRC MD stipend, DGK MD stipend, DZHK MD stipend, etc.).

We are a young and dynamic multidisciplinary group including physicians, pharmacists, biologists and chemists. The Cardiovascular Physiology is part of the European Center for Angioscience (ECAS) and very well connected with other institutes.

In summary

What we want:
- Motivated MD students with strong interest in science
- Willingness to learn new techniques
- Willingness to handle animal samples
- Willingness to work for one year in full time

What we offer:
- Full integration into a young and dynamic team
- Training in state-of-the-art molecular and cell biology techniques
- Close mentoring and supervision with a regular contact person
- Option to do a training course for in vivo experiments (including learning mouse echocardiography)
- Support for application for stipends and scholarships
- Defined subproject

If you are interested, please contact Dr. Jeanette Eresch:


Betreuerin / Betreuer

Dr. Jeanette Eresch

Doktormutter / Doktorvater

Prof. Dr. Jörg Heineke


European Center for Angioscience Medizin

Für Studierende der Fächer ...




Abschluss / Akademischer Grad

Dr. med

Start der Arbeit


Voraussichtliche Dauer in Monaten


Ungefährer Arbeitsaufwand

12 Monate Vollzeit

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