Innate immune checkpoints play an important role in modulating immune responses to brain tumors. We use mouse models and patient blood and tissue from brain tumor immunotherapy trials we conduct to identify the impact of such innate immune checkpoints on response to immunotherapy. Complementary to a PhD thesis this MD project focusses on dietary and microbial determinants innate immune checkpoints in brain tumors. This project will employ sequencing-based methodologies on brain tumor animal models with defined dietary interventions and patient tissue as well as data from gut microbial specimens to identify such dietary and microbial parameters governing innate immune checkpoints in brain tumors. The project will be jointly supervised by the PIs Karharina Sahm and Michael Platten (University Hospital Mannheim) as well as David Vonhören, the PhD student from the previous cohort of PhD students.
Please send your application to
katharina.sahm@medma.uni-heidelberg.de;
michael.platten@medma.uni-heidelberg.de;
martin.schneider@medma.uni-heidelberg.de