Immune checkpoint inhibitors (ICI) have emerged as an important part of cancer immunotherapy. However, they may increase the risk for adverse cardiovascular events. We hypothesis that expression of immune checkpoints in the heart is altered in response to ischemia or metabolic stress. Understanding a changing landscape of immune checkpoints in the failing heart, could allow for identification of patients at risk and to design ICI strategies mitigating side effects. This project will apply RNA analysis and immunofluorescence imaging to unravel IC expression and its potential changes in disease.
Please send your application to
christian.schulz@medma.uni-heidelberg.de;
martin.schneider@medma.uni-heidelberg.de