European Center for Angioscience

Vascular Cells As Target During Organ Fibrosis
Abschluss: Dr. med., M.Sc., ggf. Pharm. PJ
Art: experimentell, ggf. tierexperimentell
Für Studierende der: Medizin, Biowiss., Pharmazie
Start: jederzeit
voraussichtliche Dauer: 12 Monate
ungefährer Arbeitsaufwand: 12 Monate Vollzeit
Abteilung: Kardiovaskuläre Physiologie
Doktorvater / -mutter: Prof. Dr. Jörg Heineke
Betreuer: Dr. Felix A. Trogisch
Ansprechpartner: Dr. Felix A. Trogisch


Our group is interested in the identification of potential new targets as well as mechanisms involved in the progression of organ fibrosis, dysfunction and failure with special regard (but not limited) to the heart (

The prospective candidate will work in a project that targets the role of vascular cells’ (e.g., endothelial cells, pericytes) fate and contribution to fibrotic disease. To this end, cultured cells and transgenic mice are challenged with experimental fibrotic stimuli (e.g., myocardial infarction, hypertensive metabolic disease, aortic stenosis) and subsequently processed for histologic, protein, and RNA analytical approaches, and many more. Depending on personal interest and project progress, the candidate will analyze tissue samples (staining, microscopy, Western blotting, qPCR), isolate cells for specific analysis, work with cellular models, and physiologically monitor (analyze or/and conduct) in vivo approaches. If desired, we support training courses for in vivo experiments to enable you to perform these independently. Lab experience is welcome but you will be taught intensively in all techniques in our lab until independent work.

Our lab is expert in biomedical analytical methods such as histology/immunofluorescence, Western blotting, qPCR and more specialized methods like several sequencing methods (“OMICS”). Moreover, we are outstanding in experimental animal approaches which is reflected in several collaborations inside and outside the HD/MA environment. If interested, the candidate can be part of the core facility “Cardiac Imaging Center” ( Even though extensive experimental animal work by the candidate is not necessarily required, willingness to work with animal samples and handle animals (mice) is inevitable.

The prospective candidate will experience regular feedback and have a regular contact person. We offer a strong focus to personal scientific development like project planning, presentation skills and data consolidation. We also support the application for MD Fellowships (1034€/month) by intra- or extramural stipends (Promotionsstipendium der medizinischen Fakultät Manheim, CRC MD stipend, DGK MD stipend, DZHK MD stipend, etc.).

What we want:
- Motivated students with strong interest in science
- Willingness to learn and establish new techniques
- Willingness to work for one year in full time
- Willingness to handle experimental animals

What we offer:
- Full integration into a young and dynamic team
- Training in-state-of-the-art molecular and cell biology techniques
- Close mentoring and supervision
- Option to do a training course for in vivo experiments (including learning ultrasound techniques in mice)
- Support for application for stipends and scholarships
- Defined subproject

If you are interested, please contact Dr. Felix A. Trogisch:
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